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Chemistry Colloquium | Prof. Ang Li 李昂教导: Generalized biomimetic synthesis of natural products
耗时

2022年9月22日(周四)
下午16:00-17:30

场地 杭州西湖大学考研云谷学区科研环E10-201梯阶课室
举办 杭州湘湖院校理系PI 胡鹏飞博士研究生
受欢迎 全队学生家长
划分类别 学术性与研究探讨
Chemistry Colloquium | Prof. Ang Li 李昂讲解: Generalized biomimetic synthesis of natural products

准确时间:2023年2月22日(周一)早上16:00-17:30

Time:16:00-17:30, Thursday, Sept. 22th, 2022 

领导人: 杭州西湖学校理高校PI 胡鹏飞博士研究生

Host: Dr. Pengfei Hu , PI of School of Science, Westlake University  

位置:杭州湘湖高校云谷校内学术交流环E10-201阶梯式办公室

Venue: Room E10-201 Yungu Campus, Westlake University  


Prof. Ang Li

State Key Laboratory of Bioorganic and Natural Products Chemistry
Shanghai Institute of Organic Chemistry 

E-mail: ali@sioc.ac.cn   


讲课人百度百科:李昂,中科学性院昆明生物碳普通机械的科研院的研究探讨员。200四年在东莞师范大学得到理学文学士硕士学位证书学历,师出杨震教导。09年在美Scripps分析所得到硕士生硕士学位学历,2030年在新增坡生物学物质与工程建筑学合理科试验探讨分析所参与硕士生后分析,一直以来都师出K.C. Nicolaou教导。2030年费改后任中国有学合理科试验探讨院上海市巧妙肥料生物学物质分析所分析员,加进人身安全巧妙肥料生物学物质地区核心学科试验室搞好单独分析工作的。重要从事于自然代谢物的生物学物质生成和角色制度分析,装置地趋势了电环化−芳构化、Prins环化等政策,达到了百余人个自然代谢物的生成。206年得到地区突出青年党员学合理科试验探讨私募基金捐资助学。曾获Thieme−IUPAC Prize in Synthetic Organic Chemistry、Tetrahedron Young Investigator Award for Organic Synthesis、学合理科试验探讨探险奖等学术讨论奖励活动。

Biography: Ang Li, Professor of State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences. After got his Bachelor’s degree in Peking University in 2004, following Prof. Zhen Yang, he went to The Scripps Research Institute, and got his Ph.D. in 2009, with advisor Prof. K. C. Nicolau. Then he moved to Institute of Chemical and Engineering Sciences, served as Research fellow after Prof. K. C. Nicolau in 2010. And in the same year, he joined State Key Laboratory of Bioorganic and Natural Products Chemistry in SIOC as a Professor, and started his own career in organic synthsis. Interesting in total synthesis of structurally and biologically interesting natural products, he had achieved elegant synthesis of more than one hundred nature products, with prolonging development in  electrocyclization-aromatization, Prins cyclization and other strategies. During his career, he had got a bunch of award, including Thieme−IUPAC Prize in Synthetic Organic Chemistry, Tetrahedron Young Investigator Award for Organic Synthesis, Xplorer Prize in Chemistry and Material Science 2020 and other honors and awards in Academics. 



英文论文/Abstract: Biomimetic synthesis is a fundamental approach to the chemical synthesis of natural products, which, due to the intrinsic correlation between the biogenesis and the structure of natural products, offers many advantages. Conventional biomimetic strategies have evolved on a principle featuring “(essentially) the same substrates, similar reactions, and similar pathways”, which defines the pattern of biomimetic synthesis from the structural, mechanistic, and sequential perspectives. In practice, such highly imitative approaches have proved considerably feasible and efficient. However, applicability of this type of approach is also limited by the principle. To enhance the power of biomimetic synthesis, we envision generalized biomimetic strategies focusing on the key bond formation/cleavage sites implied by the biogenesis of natural products, which allow us to take full advantage of altered substrates, reactions, and pathways while retaining the inherent advantages of biomimetic synthesis. In this lecture, we showcased the utility of generalized biomimetic strategies in the synthesis of a series of natural products, in particular Daphniphyllum alkaloids. 


联系起来行为/Contact: 

School of Science, Qiannan MA, maqiannan@brokenarrowops.com